| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MOCS3 (271-460) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MOCS3 |
| Gene ID: |
27304 |
| Uniprot ID: |
MOCS3_HUMAN |
| Immunogen Region: |
271-460 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 271-460 of human MOCS3 (NP_055299.1). |
| Immunogen Sequence: |
YSGSLLLFDALRGHFRSIRL RSRRLDCAACGERPTVTDLL DYEAFCGSSATDKCRSLQLL SPEERVSVTDYKRLLDSGAF HLLLDVRPQVEVDICRLPHA LHIPLKHLERRDAESLKLLK EAIWEEKQGTQEGAAVPIYV ICKLGNDSQKAVKILQSLSA AQELDPLTVRDVVGGLMAWA AKIDGTFPQY |
| Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor.NFS1 acting as a sulfur donor for thiocarboxylation reactions. |
| Protein Name | Adenylyltransferase And Sulfurtransferase Mocs3Molybdenum Cofactor Synthesis Protein 3Molybdopterin Synthase SulfurylaseMpt Synthase Sulfurylase Includes - Molybdopterin-Synthase AdenylyltransferaseAdenylyltransferase Mocs3Sulfur Carrier Protein Mocs2a Adenylyltransferase - Molybdopterin-Synthase SulfurtransferaseSulfur Carrier Protein Mocs2a SulfurtransferaseSulfurtransferase Mocs3 |
| Database Links | Reactome: R-HSA-947581 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Adenylyltransferase And Sulfurtransferase Mocs3 antibodyAnti-Molybdenum Cofactor Synthesis Protein 3 antibodyAnti-Molybdopterin Synthase Sulfurylase antibodyAnti-Mpt Synthase Sulfurylase Includes - Molybdopterin-Synthase Adenylyltransferase antibodyAnti-Adenylyltransferase Mocs3 antibodyAnti-Sulfur Carrier Protein Mocs2a Adenylyltransferase - Molybdopterin-Synthase Sulfurtransferase antibodyAnti-Sulfur Carrier Protein Mocs2a Sulfurtransferase antibodyAnti-Sulfurtransferase Mocs3 antibodyAnti-MOCS3 antibodyAnti-UBA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
