| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MNAT1 |
| Gene ID: | 4331 |
| Uniprot ID: | MAT1_HUMAN |
| Immunogen Region: | 1-309 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human MNAT1 (NP_002422.1). |
| Immunogen Sequence: | MDDQGCPRCKTTKYRNPSLK LMVNVCGHTLCESCVDLLFV RGAGNCPECGTPLRKSNFRV QLFEDPTVDKEVEIRKKVLK IYNKREEDFPSLREYNDFLE EVEEIVFNLTNNVDLDNTKK KMEIYQKENKDVIQKNKLKL TREQEELEEALEVERQENEQ RRLFIQKEEQLQQILKRKNK QAFLDELESSDLPVALLLAQ HKDRSTQLEMQLEKPKPVKP VTFSTGIKMGQHISLAPIH |
| Tissue Specificity | Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes. |
| Function | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. |
| Protein Name | Cdk-Activating Kinase Assembly Factor Mat1 Cdk7/Cyclin-H Assembly Factor Cyclin-G1-Interacting Protein Menage A Trois Ring Finger Protein 66 Ring Finger Protein Mat1 P35 P36 |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-113418 Reactome: R-HSA-167152 Reactome: R-HSA-167158 Reactome: R-HSA-167160 Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-167200 Reactome: R-HSA-167246 Reactome: R-HSA-427413 Reactome: R-HSA-5696395 Reactome: R-HSA-674695 Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-6796648 Reactome: R-HSA-69202 Reactome: R-HSA-69231 Reactome: R-HSA-69273 Reactome: R-HSA-69656 Reactome: R-HSA-72086 Reactome: R-HSA-73762 Reactome: R-HSA-73772 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-73863 Reactome: R-HSA-75953 Reactome: R-HSA-75955 Reactome: R-HSA-76042 Reactome: R-HSA-77075 Reactome: R-HSA-8939236 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cdk-Activating Kinase Assembly Factor Mat1 antibody Anti-Cdk7/Cyclin-H Assembly Factor antibody Anti-Cyclin-G1-Interacting Protein antibody Anti-Menage A Trois antibody Anti-Ring Finger Protein 66 antibody Anti-Ring Finger Protein Mat1 antibody Anti-P35 antibody Anti-P36 antibody Anti-MNAT1 antibody Anti-CAP35 antibody Anti-MAT1 antibody Anti-RNF66 antibody |
Information sourced from Uniprot.org