Anti-MMP19 antibody (209-508) (STJ28740)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MMP19 (209-508) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP19 |
| Gene ID | 4327 |
| Uniprot ID | MMP19_HUMAN |
| Immunogen Region | 209-508 |
| Immunogen Sequence | IAAHEVGHALGLGHSRYSQA LMAPVYEGYRPHFKLHPDDV AGIQALYGKKSPVIRDEEEE ETELPTVPPVPTEPSPMPDP CSSELDAMMLGPRGKTYAFK GDYVWTVSDSGPGPLFRVSA LWEGLPGNLDAAVYSPRTQW IHFFKGDKVWRYINFKMSPG FPKKLNRVEPNLDAALYWPL NQKVFLFKGSGYWQWDELAR TDFSSYPKPIKGLFTGVPNQ PSAAMSWQDGRVYFFKGKV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human MMP19 (NP_002420.1). |
Additional Info
| Tissue Specificity | Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients. |
| Post Translational Modifications | Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. |
| Protein Name | Matrix Metalloproteinase-19Mmp-19Matrix Metalloproteinase RasiMatrix Metalloproteinase-18Mmp-18 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-19 antibodyAnti-Mmp-19 antibodyAnti-Matrix Metalloproteinase Rasi antibodyAnti-Matrix Metalloproteinase-18 antibodyAnti-Mmp-18 antibodyAnti-MMP19 antibodyAnti-MMP18 antibodyAnti-RASI antibody |
Information sourced from Uniprot.org