| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MMP19 (209-508) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MMP19 |
| Gene ID: |
4327 |
| Uniprot ID: |
MMP19_HUMAN |
| Immunogen Region: |
209-508 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human MMP19 (NP_002420.1). |
| Immunogen Sequence: |
IAAHEVGHALGLGHSRYSQA LMAPVYEGYRPHFKLHPDDV AGIQALYGKKSPVIRDEEEE ETELPTVPPVPTEPSPMPDP CSSELDAMMLGPRGKTYAFK GDYVWTVSDSGPGPLFRVSA LWEGLPGNLDAAVYSPRTQW IHFFKGDKVWRYINFKMSPG FPKKLNRVEPNLDAALYWPL NQKVFLFKGSGYWQWDELAR TDFSSYPKPIKGLFTGVPNQ PSAAMSWQDGRVYFFKGKV |
| Tissue Specificity | Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients. |
| Post Translational Modifications | Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. |
| Protein Name | Matrix Metalloproteinase-19Mmp-19Matrix Metalloproteinase RasiMatrix Metalloproteinase-18Mmp-18 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-19 antibodyAnti-Mmp-19 antibodyAnti-Matrix Metalloproteinase Rasi antibodyAnti-Matrix Metalloproteinase-18 antibodyAnti-Mmp-18 antibodyAnti-MMP19 antibodyAnti-MMP18 antibodyAnti-RASI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
