Anti-MMP19 antibody (11-60) (STJ94162)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MMP-19. AA range:11-60
General Information
| Short Description | Rabbit polyclonal anti-Matrix metalloproteinase-19 (11-60) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP19 |
| Gene ID | 4327 |
| Uniprot ID | MMP19_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP-19. AA range:11-60 |
| Immunogen Region | 11-60 |
| Specificity | MMP-19 Polyclonal Antibody detects endogenous levels of MMP-19 protein. |
Additional Info
| Tissue Specificity | Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients. |
| Post Translational Modifications | Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. |
| Protein Name | Matrix Metalloproteinase-19Mmp-19Matrix Metalloproteinase RasiMatrix Metalloproteinase-18Mmp-18 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-19 antibodyAnti-Mmp-19 antibodyAnti-Matrix Metalloproteinase Rasi antibodyAnti-Matrix Metalloproteinase-18 antibodyAnti-Mmp-18 antibodyAnti-MMP19 antibodyAnti-MMP18 antibodyAnti-RASI antibody |
Information sourced from Uniprot.org