| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Matrix metalloproteinase-19 (11-60) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MMP19 |
| Gene ID: | 4327 |
| Uniprot ID: | MMP19_HUMAN |
| Immunogen Region: | 11-60 |
| Specificity: | MMP-19 Polyclonal Antibody detects endogenous levels of MMP-19 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human MMP-19. AA range:11-60 |
| Tissue Specificity | Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients. |
| Post Translational Modifications | Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. |
| Protein Name | Matrix Metalloproteinase-19 Mmp-19 Matrix Metalloproteinase Rasi Matrix Metalloproteinase-18 Mmp-18 |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-19 antibody Anti-Mmp-19 antibody Anti-Matrix Metalloproteinase Rasi antibody Anti-Matrix Metalloproteinase-18 antibody Anti-Mmp-18 antibody Anti-MMP19 antibody Anti-MMP18 antibody Anti-RASI antibody |
Information sourced from Uniprot.org