Anti-MKS1 antibody (150-300) (STJ26874)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MKS1 (150-300) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MKS1 |
| Gene ID | 54903 |
| Uniprot ID | MKS1_HUMAN |
| Immunogen Region | 150-300 |
| Immunogen Sequence | EVPSFLVERMANVRRRRQDR RGMEGGILKSRIVTWEPSEE FVRNNHVINTPLQTMHIMAD LGPYKKLGYKKYEHVLCTLK VDSNGVITVKPDFTGLKGPY RIETEGEKQELWKYTIDNVS PHAQPEEEERERRVFKDLYG RHKEYLSSLVG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 150-300 of human MKS1 (NP_060247.2). |
Additional Info
| Function | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. |
| Protein Name | Tectonic-Like Complex Member Mks1Meckel Syndrome Type 1 Protein |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeLocalizes At The Transition ZoneA Region Between The Basal Body And The Ciliary Axoneme |
| Alternative Antibody Names | Anti-Tectonic-Like Complex Member Mks1 antibodyAnti-Meckel Syndrome Type 1 Protein antibodyAnti-MKS1 antibody |
Information sourced from Uniprot.org