| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MKS1 (150-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MKS1 |
| Gene ID: |
54903 |
| Uniprot ID: |
MKS1_HUMAN |
| Immunogen Region: |
150-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 150-300 of human MKS1 (NP_060247.2). |
| Immunogen Sequence: |
EVPSFLVERMANVRRRRQDR RGMEGGILKSRIVTWEPSEE FVRNNHVINTPLQTMHIMAD LGPYKKLGYKKYEHVLCTLK VDSNGVITVKPDFTGLKGPY RIETEGEKQELWKYTIDNVS PHAQPEEEERERRVFKDLYG RHKEYLSSLVG |
| Function | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. |
| Protein Name | Tectonic-Like Complex Member Mks1Meckel Syndrome Type 1 Protein |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeLocalizes At The Transition ZoneA Region Between The Basal Body And The Ciliary Axoneme |
| Alternative Antibody Names | Anti-Tectonic-Like Complex Member Mks1 antibodyAnti-Meckel Syndrome Type 1 Protein antibodyAnti-MKS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
