Anti-MKLN1 antibody (436-735) (STJ114010)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MKLN1 (436-735) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MKLN1 |
| Gene ID | 4289 |
| Uniprot ID | MKLN1_HUMAN |
| Immunogen Region | 436-735 |
| Immunogen Sequence | QTWKLLREDSCNAGPEDIQS RIGHCMLFHSKNRCLYVFGG QRSKTYLNDFFSYDVDSDHV DIISDGTKKDSGMVPMTGFT QRATIDPELNEIHVLSGLSK DKEKREENVRNSFWIYDIVR NSWSCVYKNDQAAKDNPTKS LQEEEPCPRFAHQLVYDELH KVHYLFGGNPGKSCSPKMRL DDFWSLKLCRPSKDYLLRHC KYLIRKHRFEEKAQVDPLSA LKYLQNDLYITVDHSDPEE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 436-735 of human MKLN1 (NP_037387.2). |
Additional Info
| Function | Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. |
| Protein Name | Muskelin |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | CytoplasmCytosolNucleusNucleoplasmCell ProjectionRuffleCell CortexSynapsePostsynapseColocalizes With Gabra1 At Synapses And In Postsynaptic RegionsColocalizes With Actin Fibers In The Cell Cortex |
| Alternative Antibody Names | Anti-Muskelin antibodyAnti-MKLN1 antibody |
Information sourced from Uniprot.org