| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MKLN1 (436-735) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MKLN1 |
| Gene ID: |
4289 |
| Uniprot ID: |
MKLN1_HUMAN |
| Immunogen Region: |
436-735 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 436-735 of human MKLN1 (NP_037387.2). |
| Immunogen Sequence: |
QTWKLLREDSCNAGPEDIQS RIGHCMLFHSKNRCLYVFGG QRSKTYLNDFFSYDVDSDHV DIISDGTKKDSGMVPMTGFT QRATIDPELNEIHVLSGLSK DKEKREENVRNSFWIYDIVR NSWSCVYKNDQAAKDNPTKS LQEEEPCPRFAHQLVYDELH KVHYLFGGNPGKSCSPKMRL DDFWSLKLCRPSKDYLLRHC KYLIRKHRFEEKAQVDPLSA LKYLQNDLYITVDHSDPEE |
| Function | Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. |
| Protein Name | Muskelin |
| Cellular Localisation | CytoplasmCytosolNucleusNucleoplasmCell ProjectionRuffleCell CortexSynapsePostsynapseColocalizes With Gabra1 At Synapses And In Postsynaptic RegionsColocalizes With Actin Fibers In The Cell Cortex |
| Alternative Antibody Names | Anti-Muskelin antibodyAnti-MKLN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
