Anti-MISP antibody (STJA0007562)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human C19orf21
General Information
| Short Description | Rabbit polyclonal anti-Mitotic interactor and substrate of PLK1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MISP |
| Gene ID | 126353 |
| Uniprot ID | MISP_HUMAN |
| Immunogen | Synthesized peptide derived from human C19orf21 |
| Specificity | This antibody detects endogenous levels of C19orf21 at Human, Mouse |
Additional Info
| Function | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. |
| Protein Name | Mitotic Interactor And Substrate Of Plk1Mitotic Spindle Positioning Protein |
| Database Links | |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeletonCell CortexPredominantly Localizes To Cortical Actin Structures During Interphase And MitosisPresent In Retraction FibersWhich Are Formed At Former Adhesion Sites During MitosisAnd At Spicular Membrane Protrusions In Re-Attaching Cytokinetic CellsPartially Colocalizes With Cytoplasmic F-ActinNot Detected At Microtubules At InterphaseNor At Spindle During Mitosis |
| Alternative Antibody Names | Anti-Mitotic Interactor And Substrate Of Plk1 antibodyAnti-Mitotic Spindle Positioning Protein antibodyAnti-MISP antibodyAnti-C19orf21 antibody |
Information sourced from Uniprot.org