| Function | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. |
| Protein Name | Mitotic Interactor And Substrate Of Plk1Mitotic Spindle Positioning Protein |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeletonCell CortexPredominantly Localizes To Cortical Actin Structures During Interphase And MitosisPresent In Retraction FibersWhich Are Formed At Former Adhesion Sites During MitosisAnd At Spicular Membrane Protrusions In Re-Attaching Cytokinetic CellsPartially Colocalizes With Cytoplasmic F-ActinNot Detected At Microtubules At InterphaseNor At Spindle During Mitosis |
| Alternative Antibody Names | Anti-Mitotic Interactor And Substrate Of Plk1 antibodyAnti-Mitotic Spindle Positioning Protein antibodyAnti-MISP antibodyAnti-C19orf21 antibody |
Information sourced from Uniprot.org
