| Post Translational Modifications | Autophosphorylated. |
| Function | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Protein Name | Misshapen-Like Kinase 1Gck Family Kinase MinkMapk/Erk Kinase Kinase Kinase 6Mek Kinase Kinase 6Mekkk 6Misshapen/Nik-Related KinaseMitogen-Activated Protein Kinase Kinase Kinase Kinase 6 |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | CytoplasmPostsynaptic DensityCell ProjectionAxonDendriteIsoform 4: Golgi Apparatus |
| Alternative Antibody Names | Anti-Misshapen-Like Kinase 1 antibodyAnti-Gck Family Kinase Mink antibodyAnti-Mapk/Erk Kinase Kinase Kinase 6 antibodyAnti-Mek Kinase Kinase 6 antibodyAnti-Mekkk 6 antibodyAnti-Misshapen/Nik-Related Kinase antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 6 antibodyAnti-MINK1 antibodyAnti-B55 antibodyAnti-MAP4K6 antibodyAnti-MINK antibodyAnti-YSK2 antibodyAnti-ZC3 antibody |
Information sourced from Uniprot.org
