• Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
  • Western blot analysis of lysates from COLO cells, using MAP4K6 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using MINK1 Polyclonal Antibody diluted at 1：1000

Anti-MINK1 antibody (401-450 aa) (STJ94129)

SKU:
STJ94129

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Misshapen-like kinase 1 (401-450 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MINK1
Gene ID: 50488
Uniprot ID: MINK1_HUMAN
Immunogen Region: 401-450 aa
Specificity: MINK1 Polyclonal Antibody detects endogenous levels of MINK1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MAP4K6 at the amino acid range 401-450
Post Translational Modifications Autophosphorylated.
Function Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Protein Name Misshapen-Like Kinase 1
Gck Family Kinase Mink
Mapk/Erk Kinase Kinase Kinase 6
Mek Kinase Kinase 6
Mekkk 6
Misshapen/Nik-Related Kinase
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 6
Database Links Reactome: R-HSA-2559580
Cellular Localisation Cytoplasm
Postsynaptic Density
Cell Projection
Axon
Dendrite
Isoform 4: Golgi Apparatus
Alternative Antibody Names Anti-Misshapen-Like Kinase 1 antibody
Anti-Gck Family Kinase Mink antibody
Anti-Mapk/Erk Kinase Kinase Kinase 6 antibody
Anti-Mek Kinase Kinase 6 antibody
Anti-Mekkk 6 antibody
Anti-Misshapen/Nik-Related Kinase antibody
Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 6 antibody
Anti-MINK1 antibody
Anti-B55 antibody
Anti-MAP4K6 antibody
Anti-MINK antibody
Anti-YSK2 antibody
Anti-ZC3 antibody

Information sourced from Uniprot.org

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