Anti-MIEF1 antibody (40-280) (STJ112432)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MIEF1 (40-280) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MIEF1 |
| Gene ID | 54471 |
| Uniprot ID | MID51_HUMAN |
| Immunogen Region | 40-280 |
| Immunogen Sequence | GIATLAVKRMYDRAISAPTS PTRLSHSGKRSWEEPNWMGS PRLLNRDMKTGLSRSLQTLP TDSSTFDTDTFCPPRPKPVA RKGQVDLKKSRLRMSLQEKL LTYYRNRAAIPAGEQARAKQ AAVDICAELRSFLRAKLPDM PLRDMYLSGSLYDDLQVVTA DHIQLIVPLVLEQNLWSCIP GEDTIMNVPGFFLVRRENPE YFPRGSSYWDRCVVGGYLSP KTVADTFEKVVAGSINWPA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MIEF1 (NP_061881.2). |
Additional Info
| Tissue Specificity | Expression is relatively high in heart, skeletal muscle, pancreas and kidney. |
| Function | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. |
| Protein Name | Mitochondrial Dynamics Protein Mief1Mitochondrial Dynamics Protein Of 51 KdaMitochondrial Elongation Factor 1Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-LikeSmcr7-Like Protein |
| Database Links | |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Dynamics Protein Mief1 antibodyAnti-Mitochondrial Dynamics Protein Of 51 Kda antibodyAnti-Mitochondrial Elongation Factor 1 antibodyAnti-Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like antibodyAnti-Smcr7-Like Protein antibodyAnti-MIEF1 antibodyAnti-MID51 antibodyAnti-SMCR7L antibody |
Information sourced from Uniprot.org