| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MIEF1 (40-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MIEF1 |
| Gene ID: |
54471 |
| Uniprot ID: |
MID51_HUMAN |
| Immunogen Region: |
40-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MIEF1 (NP_061881.2). |
| Immunogen Sequence: |
GIATLAVKRMYDRAISAPTS PTRLSHSGKRSWEEPNWMGS PRLLNRDMKTGLSRSLQTLP TDSSTFDTDTFCPPRPKPVA RKGQVDLKKSRLRMSLQEKL LTYYRNRAAIPAGEQARAKQ AAVDICAELRSFLRAKLPDM PLRDMYLSGSLYDDLQVVTA DHIQLIVPLVLEQNLWSCIP GEDTIMNVPGFFLVRRENPE YFPRGSSYWDRCVVGGYLSP KTVADTFEKVVAGSINWPA |
| Tissue Specificity | Expression is relatively high in heart, skeletal muscle, pancreas and kidney. |
| Function | Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. |
| Protein Name | Mitochondrial Dynamics Protein Mief1Mitochondrial Dynamics Protein Of 51 KdaMitochondrial Elongation Factor 1Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-LikeSmcr7-Like Protein |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Dynamics Protein Mief1 antibodyAnti-Mitochondrial Dynamics Protein Of 51 Kda antibodyAnti-Mitochondrial Elongation Factor 1 antibodyAnti-Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like antibodyAnti-Smcr7-Like Protein antibodyAnti-MIEF1 antibodyAnti-MID51 antibodyAnti-SMCR7L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
