| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MIEF1 |
| Gene ID: | 54471 |
| Uniprot ID: | MID51_HUMAN |
| Immunogen Region: | 40-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MIEF1 (NP_061881.2). |
| Immunogen Sequence: | GIATLAVKRMYDRAISAPTS PTRLSHSGKRSWEEPNWMGS PRLLNRDMKTGLSRSLQTLP TDSSTFDTDTFCPPRPKPVA RKGQVDLKKSRLRMSLQEKL LTYYRNRAAIPAGEQARAKQ AAVDICAELRSFLRAKLPDM PLRDMYLSGSLYDDLQVVTA DHIQLIVPLVLEQNLWSCIP GEDTIMNVPGFFLVRRENPE YFPRGSSYWDRCVVGGYLSP KTVADTFEKVVAGSINWPA |
| Tissue Specificity | Expression is relatively high in heart, skeletal muscle, pancreas and kidney. |
| Function | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. |
| Protein Name | Mitochondrial Dynamics Protein Mief1 Mitochondrial Dynamics Protein Of 51 Kda Mitochondrial Elongation Factor 1 Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like Smcr7-Like Protein |
| Cellular Localisation | Mitochondrion Outer Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Dynamics Protein Mief1 antibody Anti-Mitochondrial Dynamics Protein Of 51 Kda antibody Anti-Mitochondrial Elongation Factor 1 antibody Anti-Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like antibody Anti-Smcr7-Like Protein antibody Anti-MIEF1 antibody Anti-MID51 antibody Anti-SMCR7L antibody |
Information sourced from Uniprot.org