| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MEF2C (170-473) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MEF2C |
| Gene ID: |
4208 |
| Uniprot ID: |
MEF2C_HUMAN |
| Immunogen Region: |
170-473 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-473 of human MEF2C (NP_002388.2). |
| Immunogen Sequence: |
LPLAHPSLQRNSMSPGVTHR PPSAGNTGGLMGGDLTSGAG TSAGNGYGNPRNSPGLLVSP GNLNKNMQAKSPPPMNLGMN NRKPDLRVLIPPGSKNTMPS VSEDVDLLLNQRINNSQSAQ SLATPVVSVATPTLPGQGMG GYPSAISTTYGTEYSLSSAD LSSLSGFNTASALHLGSVTG WQQQHLHNMPPSALSQLGAC TSTHLSQSSNL |
| Tissue Specificity | Expressed in brain and skeletal muscle. |
| Post Translational Modifications | Phosphorylation on Ser-59 enhances DNA binding activity. Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation. Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation. |
| Function | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1. |
| Protein Name | Myocyte-Specific Enhancer Factor 2cMyocyte Enhancer Factor 2c |
| Database Links | Reactome: R-HSA-198753Reactome: R-HSA-2151201Reactome: R-HSA-400253Reactome: R-HSA-525793Reactome: R-HSA-9022707Reactome: R-HSA-9707616Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusCytoplasmSarcoplasm |
| Alternative Antibody Names | Anti-Myocyte-Specific Enhancer Factor 2c antibodyAnti-Myocyte Enhancer Factor 2c antibodyAnti-MEF2C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
