| Tissue Specificity | Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 25Activator Interaction Domain-Containing Protein 1Activator-Recruited Cofactor 92 Kda ComponentArc92Mediator Complex Subunit 25P78 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 25 antibodyAnti-Activator Interaction Domain-Containing Protein 1 antibodyAnti-Activator-Recruited Cofactor 92 Kda Component antibodyAnti-Arc92 antibodyAnti-Mediator Complex Subunit 25 antibodyAnti-P78 antibodyAnti-MED25 antibodyAnti-ACID1 antibodyAnti-ARC92 antibodyAnti-PTOV2 antibodyAnti-TCBAP0758 antibody |
Information sourced from Uniprot.org
