Anti-HHLA2 antibody (30-200) (STJ115227)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HHLA2 (30-200) antibody for use in WB, IHC-P and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HHLA2 |
| Gene ID | 11148 |
| Uniprot ID | HHLA2_HUMAN |
| Immunogen Region | 30-200 |
| Immunogen Sequence | IYVPMNEQIVIGRLDEDIIL PSSFERGSEVVIHWKYQDSY KVHSYYKGSDHLESQDPRYA NRTSLFYNEIQNGNASLFFR RVSLLDEGIYTCYVGTAIQV ITNKVVLKVGVFLTPVMKYE KRNTNSFLICSVLSVYPRPI ITWKMDNTPISENNMEETGS LDSFSINSPLN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human HHLA2 (NP_009003.1). |
Additional Info
| Tissue Specificity | Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells. |
| Function | Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. |
| Protein Name | Herv-H Ltr-Associating Protein 2Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Herv-H Ltr-Associating Protein 2 antibodyAnti-Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 antibodyAnti-HHLA2 antibody |
Information sourced from Uniprot.org