| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MEAF6 (1-191) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MEAF6 |
| Gene ID: |
64769 |
| Uniprot ID: |
EAF6_HUMAN |
| Immunogen Region: |
1-191 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human MEAF6 (NP_001257804.1). |
| Immunogen Sequence: |
MAMHNKAAPPQIPDTRRELA ELVKRKQELAETLANLERQI YAFEGSYLEDTQMYGNIIRG WDRYLTNQKNSNSKNDRRNR KFKEAERLFSKSSVTSAAAV SALAGVQDQLIEKREPGSGT ESDTSPDFHNQENEPSQEDP EDLDGSVQGVKPQKAASSTS SGSHHSSHKKRKNKNRHRID LKLNKKPRADY |
| Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. |
| Protein Name | Chromatin Modification-Related Protein Meaf6Myst/Esa1-Associated Factor 6Esa1-Associated Factor 6 HomologProtein Eaf6 HomologHeaf6Sarcoma Antigen Ny-Sar-91 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-6804758 |
| Cellular Localisation | NucleusNucleolusChromosomeCentromereKinetochore |
| Alternative Antibody Names | Anti-Chromatin Modification-Related Protein Meaf6 antibodyAnti-Myst/Esa1-Associated Factor 6 antibodyAnti-Esa1-Associated Factor 6 Homolog antibodyAnti-Protein Eaf6 Homolog antibodyAnti-Heaf6 antibodyAnti-Sarcoma Antigen Ny-Sar-91 antibodyAnti-MEAF6 antibodyAnti-C1orf149 antibodyAnti-CENP-28 antibodyAnti-EAF6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and PDCD6 knockout (KO) 293T cells, using [KO Validated] PDCD6 Rabbit polyclonal antibody (STJ11100800) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89736/358213/STJ11100800_1__35533.1713122537.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and PDCD6 knockout (KO) 293T cells, using [KO Validated] PDCD6 Rabbit polyclonal antibody (STJ11100800) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")