Anti-MDR1 antibody (600-700) [ABT252] (STJA0039038)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from human MDR1 AA range: 600-700
General Information
| Short Description | Mouse monoclonal anti-Atp-Dependent Translocase Abcb1 (600-700) for use in IHC, WB, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB/IF/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT252 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Protein G |
| Dilution Range | IHC 1:200-1000WB 1:500-2000IF 1:100-500ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB1 |
| Gene ID | 5243 |
| Uniprot ID | MDR1_HUMAN |
| Immunogen | Synthesized peptide derived from human MDR1 AA range: 600-700 |
| Immunogen Region | 600-700 |
| Specificity | The antibody can specifically recognize human MDR1 protein. |
Additional Info
| Function | Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Protein Name | Atp-Dependent Translocase Abcb1Atp-Binding Cassette Sub-Family B Member 1Multidrug Resistance Protein 1P-Glycoprotein 1Phospholipid Transporter Abcb1Cd Antigen Cd243 |
| Database Links | Reactome: R-HSA-2161517Reactome: R-HSA-382556Reactome: R-HSA-9754706Reactome: R-HSA-9757110 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmAbcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)Localized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Dependent Translocase Abcb1 antibodyAnti-Atp-Binding Cassette Sub-Family B Member 1 antibodyAnti-Multidrug Resistance Protein 1 antibodyAnti-P-Glycoprotein 1 antibodyAnti-Phospholipid Transporter Abcb1 antibodyAnti-Cd Antigen Cd243 antibodyAnti-ABCB1 antibodyAnti-MDR1 antibodyAnti-PGY1 antibody |
Information sourced from Uniprot.org