| Function | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity. |
| Protein Name | Colorectal Mutant Cancer ProteinProtein Mcc |
| Cellular Localisation | Cell MembraneCell ProjectionLamellipodiumNucleusCytoplasmColocalizes With Actin At The Leading Edge Of Polarized Cells |
| Alternative Antibody Names | Anti-Colorectal Mutant Cancer Protein antibodyAnti-Protein Mcc antibodyAnti-MCC antibody |
Information sourced from Uniprot.org
