Anti-MCC antibody (STJA0007338)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MCC
General Information
| Short Description | Rabbit polyclonal anti-Colorectal mutant cancer protein for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MCC |
| Gene ID | 4163 |
| Uniprot ID | CRCM_HUMAN |
| Immunogen | Synthesized peptide derived from human MCC |
| Specificity | This antibody detects endogenous levels of MCC at Human |
Additional Info
| Function | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity. |
| Protein Name | Colorectal Mutant Cancer ProteinProtein Mcc |
| Database Links | |
| Cellular Localisation | Cell MembraneCell ProjectionLamellipodiumNucleusCytoplasmColocalizes With Actin At The Leading Edge Of Polarized Cells |
| Alternative Antibody Names | Anti-Colorectal Mutant Cancer Protein antibodyAnti-Protein Mcc antibodyAnti-MCC antibody |
Information sourced from Uniprot.org