Anti-MBNL3 antibody (184-234 aa) (STJ193518)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human MBNL3 at the amino acid range 184-234
General Information
| Short Description | Rabbit polyclonal anti-Muscleblind-like protein 3 (184-234 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MBNL3 |
| Gene ID | 55796 |
| Uniprot ID | MBNL3_HUMAN |
| Immunogen | Synthesized peptide derived from the human MBNL3 at the amino acid range 184-234 |
| Immunogen Region | 184-234 aa |
| Specificity | This antibody detects endogenous levels of MBNL3 at Human/Mouse |
Additional Info
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. |
| Protein Name | Muscleblind-Like Protein 3Cys3his Ccg1-Required ProteinMuscleblind-Like X-Linked ProteinProtein Hchcr |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmGreater Concentration In The NucleusIn Both Dm1 And Dm2 PatientsColocalizes With Nuclear Foci Of Retained Expanded-Repeat Transcripts |
| Alternative Antibody Names | Anti-Muscleblind-Like Protein 3 antibodyAnti-Cys3his Ccg1-Required Protein antibodyAnti-Muscleblind-Like X-Linked Protein antibodyAnti-Protein Hchcr antibodyAnti-MBNL3 antibodyAnti-CHCR antibodyAnti-MBLX39 antibodyAnti-MBXL antibody |
Information sourced from Uniprot.org