| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Muscleblind-like protein 3 (184-234 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MBNL3 |
| Gene ID: |
55796 |
| Uniprot ID: |
MBNL3_HUMAN |
| Immunogen Region: |
184-234 aa |
| Specificity: |
This antibody detects endogenous levels of MBNL3 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human MBNL3 at the amino acid range 184-234 |
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. |
| Protein Name | Muscleblind-Like Protein 3Cys3his Ccg1-Required ProteinMuscleblind-Like X-Linked ProteinProtein Hchcr |
| Cellular Localisation | NucleusCytoplasmGreater Concentration In The NucleusIn Both Dm1 And Dm2 PatientsColocalizes With Nuclear Foci Of Retained Expanded-Repeat Transcripts |
| Alternative Antibody Names | Anti-Muscleblind-Like Protein 3 antibodyAnti-Cys3his Ccg1-Required Protein antibodyAnti-Muscleblind-Like X-Linked Protein antibodyAnti-Protein Hchcr antibodyAnti-MBNL3 antibodyAnti-CHCR antibodyAnti-MBLX39 antibodyAnti-MBXL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
