Anti-MBD3 antibody (1-255) (STJ24511)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MBD3 (1-255) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MBD3 |
| Gene ID | 53615 |
| Uniprot ID | MBD3_HUMAN |
| Immunogen Region | 1-255 |
| Immunogen Sequence | MERKSPSGKKFRSKPQLARY LGGSMDLSTFDFRTGKMLMS KMNKSRQRVRYDSSNQVKGK PDLNTALPVRQTASIFKQPV TKITNHPSNKVKSDPQKAVD QPRQLFWEKKLSGLNAFDIA EELVKTMDLPKGLQGVGPGC TDETLLSAIASALHTSTMPI TGQLSAAVEKNPGVWLNTTQ PLCKAFMVTDEDIRKQEELV QQVRKRLEEALMADMLAHVE ELARDGEAPLDKACAEDDD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human MBD3 (NP_001268383.1). |
Additional Info
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to methylated DNA by itself. Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 3Methyl-Cpg-Binding Protein Mbd3 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosomeNuclearIn Discrete FociDetected On ChromatinAt Promoter Regions Of Active Genes |
| Alternative Antibody Names | Anti-Methyl-Cpg-Binding Domain Protein 3 antibodyAnti-Methyl-Cpg-Binding Protein Mbd3 antibodyAnti-MBD3 antibody |
Information sourced from Uniprot.org