Anti-MBD3 antibody (1-255) (STJ24511)

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STJ24511
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Applications:WB/ELISA
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:200-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:MBD3
Gene ID:53615
Uniprot ID:MBD3_HUMAN
Immunogen Region:1-255
Immunogen Sequence:MERKSPSGKKFRSKPQLARY LGGSMDLSTFDFRTGKMLMS KMNKSRQRVRYDSSNQVKGK PDLNTALPVRQTASIFKQPV TKITNHPSNKVKSDPQKAVD QPRQLFWEKKLSGLNAFDIA EELVKTMDLPKGLQGVGPGC TDETLLSAIASALHTSTMPI TGQLSAAVEKNPGVWLNTTQ PLCKAFMVTDEDIRKQEELV QQVRKRLEEALMADMLAHVE ELARDGEAPLDKACAEDDD
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human MBD3 (NP_001268383.1).
Function Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to methylated DNA by itself. Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases.
Protein Name Methyl-Cpg-Binding Domain Protein 3
Methyl-Cpg-Binding Protein Mbd3
Database Links Reactome: R-HSA-3214815
Reactome: R-HSA-427389
Reactome: R-HSA-6804758
Reactome: R-HSA-73762
Reactome: R-HSA-8943724
Reactome: R-HSA-9679191
Reactome: R-HSA-9843940
Reactome: R-HSA-9844594
Reactome: R-HSA-9845323
Cellular Localisation Nucleus
Chromosome
Nuclear
In Discrete Foci
Detected On Chromatin
At Promoter Regions Of Active Genes
Alternative Antibody Names Anti-Methyl-Cpg-Binding Domain Protein 3 antibody
Anti-Methyl-Cpg-Binding Protein Mbd3 antibody
Anti-MBD3 antibody

Information sourced from Uniprot.org