| Short Description : | Rabbit polyclonal MAPRE3 (1-281) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAPRE3 |
| Gene ID: | 22924 |
| Uniprot ID: | MARE3_HUMAN |
| Immunogen Region: | 1-281 |
| Immunogen Sequence: | MAVNVYSTSVTSENLSRHDM LAWVNDSLHLNYTKIEQLCS GAAYCQFMDMLFPGCVHLRK VKFQAKLEHEYIHNFKVLQA AFKKMGVDKIIPVEKLVKGK FQDNFEFIQWFKKFFDANYD GKDYNPLLARQGQDVAPPPN PGDQIFNKSKKLIGTAVPQR TSPTGPKNMQTSGRLSNVAP PCILRKNPPSARNGGHETDA QILELNQQLVDLKLTVDGLE KERDFYFSKLRDIELICQE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human EB3/EB3/MAPRE3 (NP_036458.2). |
| Tissue Specificity | Predominantly expressed in brain and muscle. |
| Function | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. |
| Protein Name | Microtubule-Associated Protein Rp/Eb Family Member 3Eb1 Protein Family Member 3Ebf3End-Binding Protein 3Eb3Rp3 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonAssociated With The Microtubule NetworkDetected At The Plus End Of Microtubules |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein Rp/Eb Family Member 3 antibodyAnti-Eb1 Protein Family Member 3 antibodyAnti-Ebf3 antibodyAnti-End-Binding Protein 3 antibodyAnti-Eb3 antibodyAnti-Rp3 antibodyAnti-MAPRE3 antibody |
Information sourced from Uniprot.org
