Anti-MAP4K4 antibody (400-500 aa) [4H9E7] (STJ98133)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of HGK (aa400-500) expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Mitogen-activated protein kinase kinase kinase kinase 4 (400-500 aa) for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4H9E7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP4K4 |
| Gene ID | 9448 |
| Uniprot ID | M4K4_HUMAN |
| Immunogen | Purified recombinant fragment of HGK (aa400-500) expressed in E. Coli. |
| Immunogen Region | 400-500 aa |
| Specificity | HGK Monoclonal Antibody detects endogenous levels of HGK protein. |
Additional Info
| Function | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr-322. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4Hpk/Gck-Like Kinase HgkMapk/Erk Kinase Kinase Kinase 4Mek Kinase Kinase 4Mekkk 4Nck-Interacting Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 antibodyAnti-Hpk/Gck-Like Kinase Hgk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 4 antibodyAnti-Mek Kinase Kinase 4 antibodyAnti-Mekkk 4 antibodyAnti-Nck-Interacting Kinase antibodyAnti-MAP4K4 antibodyAnti-HGK antibodyAnti-KIAA0687 antibodyAnti-NIK antibody |
Information sourced from Uniprot.org