| Host: | Mouse |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Mitogen-activated protein kinase kinase kinase kinase 4 (400-500 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 4H9E7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP4K4 |
| Gene ID: | 9448 |
| Uniprot ID: | M4K4_HUMAN |
| Immunogen Region: | 400-500 aa |
| Specificity: | HGK Monoclonal Antibody detects endogenous levels of HGK protein. |
| Immunogen: | Purified recombinant fragment of HGK (aa400-500) expressed in E. Coli. |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr-322. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Hpk/Gck-Like Kinase Hgk Mapk/Erk Kinase Kinase Kinase 4 Mek Kinase Kinase 4 Mekkk 4 Nck-Interacting Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 antibody Anti-Hpk/Gck-Like Kinase Hgk antibody Anti-Mapk/Erk Kinase Kinase Kinase 4 antibody Anti-Mek Kinase Kinase 4 antibody Anti-Mekkk 4 antibody Anti-Nck-Interacting Kinase antibody Anti-MAP4K4 antibody Anti-HGK antibody Anti-KIAA0687 antibody Anti-NIK antibody |
Information sourced from Uniprot.org