• Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~70 kDa MAP2C/D proteins and the ~280 kDa MAP2A/B proteins.
  • Immunofluorescence of a section of adult rat hippocampus section stained with Anti-MAP2C (STJA0003677, green, 1:5,000) and an anti-FOX2 antibody (red). Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 Mu M, and free-floating sections were stained with above antibodies. The anti-MAP2C labels all MAP2 protein isotypes expressed in neuronal perikarya and dendrites.
  • Immunostaining of mixed neuron and glial cultures showing specific cytoplasmic labeling of dendrites and perikarya of neuronal cells with anti-microtubule associated protein 2C/D (STJA0003677, red, 1:2500) and specific fibroblast, astrocyte labeling with anti-vimentin (STJA0003823, green, 1:500). The blue stain is DAPI to identify nuclei.

Anti-MAP2 antibody (Full Length) [2C4] (STJA0003677)

SKU:
STJA0003677-100

$597.38
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Host: Mouse
Applications: WB/IHC/ICC
Reactivity: Bovine/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MAP2C/D (Full Length) is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: 2C4
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 100 ul in PBS + 50% Glycerol and 5 mM Sodium Azide
Purification: This antibody was protein g purified culture from supernatant.
Dilution Range: WB 1:5000
IHC 1:2500-1:10, 000
ICC 1:2500-1:10, 000
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAP2
Gene ID: 4133
Uniprot ID: MTAP2_HUMAN
Immunogen Region: Full Length
Immunogen: Full length recombinant human MAP2D protein.
Post Translational Modifications Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation.
Function The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Protein Name Microtubule-Associated Protein 2
Map-2
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Dendrite
Alternative Antibody Names Anti-Microtubule-Associated Protein 2 antibody
Anti-Map-2 antibody
Anti-MAP2 antibody

Information sourced from Uniprot.org

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