| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAK (370-435) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAK |
| Gene ID: |
4117 |
| Uniprot ID: |
MAK_HUMAN |
| Immunogen Region: |
370-435 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 370-435 of human MAK (NP_005897.1). |
| Immunogen Sequence: |
TLFPSIVKNMPTKPNGTLSH KSGRRRWGQTIFKSGDSWEE LEDYDFGASHSKKPSMGVFK EKRKKD |
| Tissue Specificity | Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated on serine and threonine residues. |
| Function | Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. |
| Protein Name | Serine/Threonine-Protein Kinase MakMale Germ Cell-Associated Kinase |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleMidbodyCell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentLocalized In Both The Connecting Cilia And The Outer Segment AxonemesLocalized Uniformly In Nuclei During InterphaseTo The Mitotic Spindle And Centrosomes During Metaphase And AnaphaseAnd Also To Midbody At Anaphase Until Telophase |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Mak antibodyAnti-Male Germ Cell-Associated Kinase antibodyAnti-MAK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/93967/375277/STJ114898_1__01767.1713142004.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
