| Tissue Specificity | Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient. |
| Function | Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK. |
| Protein Name | Mage-Like Protein 2Necdin-Like Protein 1Protein Nm15 |
| Cellular Localisation | Early EndosomeCytoplasmNucleusRecruited To Retromer-Containing Endosomes Via Interaction With Vps35Colocalizes With Clock And Bmal1 In The CytoplasmAnd With Per2 In The Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Mage-Like Protein 2 antibodyAnti-Necdin-Like Protein 1 antibodyAnti-Protein Nm15 antibodyAnti-MAGEL2 antibodyAnti-NDNL1 antibody |
Information sourced from Uniprot.org
