Anti-MAGEA1 antibody (1-309) (STJ27423)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAGEA1 (1-309) antibody for use in WB, IHC-P, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAGEA1 |
| Gene ID | 4100 |
| Uniprot ID | MAGA1_HUMAN |
| Immunogen Region | 1-309 |
| Immunogen Sequence | MSLEQRSLHCKPEEALEAQQ EALGLVCVQAATSSSSPLVL GTLEEVPTAGSTDPPQSPQG ASAFPTTINFTRQRQPSEGS SSREEEGPSTSCILESLFRA VITKKVADLVGFLLLKYRAR EPVTKAEMLESVIKNYKHCF PEIFGKASESLQLVFGIDVK EADPTGHSYVLVTCLGLSYD GLLGDNQIMPKTGFLIIVLV MIAMEGGHAPEEEIWEELSV MEVYDGREHSAYGEPRKLL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human MAGE-1/MAGE1A (NP_004979.3). |
Additional Info
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. |
| Function | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. |
| Protein Name | Melanoma-Associated Antigen 1Antigen Mz2-ECancer/Testis Antigen 1.1Ct1.1Mage-1 Antigen |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen 1 antibodyAnti-Antigen Mz2-E antibodyAnti-Cancer/Testis Antigen 1.1 antibodyAnti-Ct1.1 antibodyAnti-Mage-1 Antigen antibodyAnti-MAGEA1 antibodyAnti-MAGE1 antibodyAnti-MAGE1A antibody |
Information sourced from Uniprot.org