Anti-MAFA antibody (269-353) (STJ11103900)

Name: Anti-MAFA antibody (269-353) (STJ11103900)
SKU: STJ11103900
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103900

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Short Description	Rabbit polyclonal Transcription Factor Mafa (269-353) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	MAFA
Gene ID	389692
Uniprot ID	MAFA_HUMAN
Immunogen Region	269-353
Immunogen Sequence	QSCRFKRVQQRHILESEKCQ LQSQVEQLKLEVGRLAKERD LYKEKYEKLAGRGGPGSAGG AGFPREPSPPQAGPGGAKGT ADFFL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 269-353 of human MAFA (NP_963883.2).

Tissue Specificity	Expressed in the islets of Langerhans (at protein level).
Post Translational Modifications	Ubiquitinated, leading to its degradation by the proteasome. Phosphorylated at tyrosines.
Function	Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.
Protein Name	Transcription Factor Mafa Pancreatic Beta-Cell-Specific Transcriptional Activator Ripe3b1 Factor V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A
Database Links	Reactome: R-HSA-210745
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Transcription Factor Mafa antibody Anti-Pancreatic Beta-Cell-Specific Transcriptional Activator antibody Anti-Ripe3b1 Factor antibody Anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A antibody Anti-MAFA antibody

Information sourced from Uniprot.org