| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | M6PR |
| Gene ID: | 4074 |
| Uniprot ID: | MPRD_HUMAN |
| Immunogen Region: | 27-185 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1). |
| Immunogen Sequence: | TEEKTCDLVGEKGKESEKEL ALVKRLKPLFNKSFESTVGQ GSDTYIYIFRVCREAGNHTS GAGLVQINKSNGKETVVGRL NETHIFNGSNWIMLIYKGGD EYDNHCGKEQRRAVVMISCN RHTLADNFNPVSEERGKVQD CFYLFEMDSSLACSPEISH |
| Function | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. |
| Protein Name | Cation-Dependent Mannose-6-Phosphate ReceptorCd Man-6-P ReceptorCd-Mpr46 Kda Mannose 6-Phosphate ReceptorMpr 46 |
| Database Links | Reactome: R-HSA-432720Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cation-Dependent Mannose-6-Phosphate Receptor antibodyAnti-Cd Man-6-P Receptor antibodyAnti-Cd-Mpr antibodyAnti-46 Kda Mannose 6-Phosphate Receptor antibodyAnti-Mpr 46 antibodyAnti-M6PR antibodyAnti-MPR46 antibodyAnti-MPRD antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and M6PR knockout (KO) 293T cells, using [KO Validated] M6PR Rabbit polyclonal antibody (STJ11100783) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89719/358200/STJ11100783_1__90263.1713122520.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and M6PR knockout (KO) 293T cells, using [KO Validated] M6PR Rabbit polyclonal antibody (STJ11100783) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
