Anti-M6PR antibody (27-185) (STJ28218)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal M6PR (27-185) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | M6PR |
| Gene ID | 4074 |
| Uniprot ID | MPRD_HUMAN |
| Immunogen Region | 27-185 |
| Immunogen Sequence | TEEKTCDLVGEKGKESEKEL ALVKRLKPLFNKSFESTVGQ GSDTYIYIFRVCREAGNHTS GAGLVQINKSNGKETVVGRL NETHIFNGSNWIMLIYKGGD EYDNHCGKEQRRAVVMISCN RHTLADNFNPVSEERGKVQD CFYLFEMDSSLACSPEISH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1). |
Additional Info
| Function | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. |
| Protein Name | Cation-Dependent Mannose-6-Phosphate ReceptorCd Man-6-P ReceptorCd-Mpr46 Kda Mannose 6-Phosphate ReceptorMpr 46 |
| Database Links | Reactome: R-HSA-432720Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cation-Dependent Mannose-6-Phosphate Receptor antibodyAnti-Cd Man-6-P Receptor antibodyAnti-Cd-Mpr antibodyAnti-46 Kda Mannose 6-Phosphate Receptor antibodyAnti-Mpr 46 antibodyAnti-M6PR antibodyAnti-MPR46 antibodyAnti-MPRD antibody |
Information sourced from Uniprot.org