Anti-LY75 antibody (216-1722) (STJ112105)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LY75 (216-1722) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LY75 |
| Gene ID | 100526664/4065 |
| Uniprot ID | LY75_HUMAN |
| Immunogen Region | 216-1722 |
| Immunogen Sequence | CEDNWEKNEQFGSCYQFNTQ TALSWKEAYVSCQNQGADLL SINSAAELTYLKEKEGIAKI FWIGLNQLYSARGWEWSDHK PLNFLNWDPDRPSAPTIGGS SCARMDAESGLWQSFSCEAQ LPYVCRKPLNNTVELTDVWT YSDTRCDAGWLPNNGFCYLL VNESNSWDKAHAKCKAFSSD LISIHSLADVEVVVTKLHNE DIKEEVWIGLKNINIPTLFQ WSDGTEVTLTYWDENEPNV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 216-501 of human LY75 (NP_002340.2). |
Additional Info
| Tissue Specificity | Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B-lymphocytes. |
| Protein Name | Lymphocyte Antigen 75Ly-75C-Type Lectin Domain Family 13 Member BDec-205Gp200-Mr6Cd Antigen Cd205 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Lymphocyte Antigen 75 antibodyAnti-Ly-75 antibodyAnti-C-Type Lectin Domain Family 13 Member B antibodyAnti-Dec-205 antibodyAnti-Gp200-Mr6 antibodyAnti-Cd Antigen Cd205 antibodyAnti-LY75 antibodyAnti-CD205 antibodyAnti-CLEC13B antibody |
Information sourced from Uniprot.org