| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Leukotriene C4 synthase synthase (29-79 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LTC4S |
| Gene ID: |
4056 |
| Uniprot ID: |
LTC4S_HUMAN |
| Immunogen Region: |
29-79 aa |
| Specificity: |
This antibody detects endogenous levels of LTC4S at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human LTC4S at the amino acid range 29-79 |
| Post Translational Modifications | Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. |
| Protein Name | Leukotriene C4 SynthaseLtc4 SynthaseGlutathione S-Transferase Ltc4Leukotriene-C(4 SynthaseLeukotriene-C4 Synthase |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700Reactome: R-HSA-9026762Reactome: R-HSA-9026766 |
| Cellular Localisation | Nucleus Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneNucleus Membrane |
| Alternative Antibody Names | Anti-Leukotriene C4 Synthase antibodyAnti-Ltc4 Synthase antibodyAnti-Glutathione S-Transferase Ltc4 antibodyAnti-Leukotriene-C(4 Synthase antibodyAnti-Leukotriene-C4 Synthase antibodyAnti-LTC4S antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
