Anti-LTC4S antibody (29-79 aa) (STJ195026)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human LTC4S at the amino acid range 29-79
General Information
| Short Description | Rabbit polyclonal anti-Leukotriene C4 synthase synthase (29-79 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LTC4S |
| Gene ID | 4056 |
| Uniprot ID | LTC4S_HUMAN |
| Immunogen | Synthesized peptide derived from the human LTC4S at the amino acid range 29-79 |
| Immunogen Region | 29-79 aa |
| Specificity | This antibody detects endogenous levels of LTC4S at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. |
| Protein Name | Leukotriene C4 SynthaseLtc4 SynthaseGlutathione S-Transferase Ltc4Leukotriene-C(4 SynthaseLeukotriene-C4 Synthase |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700Reactome: R-HSA-9026762Reactome: R-HSA-9026766 |
| Cellular Localisation | Nucleus Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneNucleus Membrane |
| Alternative Antibody Names | Anti-Leukotriene C4 Synthase antibodyAnti-Ltc4 Synthase antibodyAnti-Glutathione S-Transferase Ltc4 antibodyAnti-Leukotriene-C(4 Synthase antibodyAnti-Leukotriene-C4 Synthase antibodyAnti-LTC4S antibody |
Information sourced from Uniprot.org