Anti-LTB4R antibody (320-337) (STJ117236)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LTB4R (320-337) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LTB4R |
| Gene ID | 1241 |
| Uniprot ID | LT4R1_HUMAN |
| Immunogen Region | 320-337 |
| Immunogen Sequence | AAGLGLVGKRLSLARNVLIA LAFLSSSVNPVLYACAGGGL LRSAGVGFVAKLLEGTGSEA SSTRRGGSLGQTARSGPAAL EPGPSESLTASSPLKLNELN |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 253-352 of human LTB4R (NP_001137391.1). |
Additional Info
| Tissue Specificity | Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues. |
| Post Translational Modifications | Phosphorylated by GRK6 upon leukotriene B4 binding.which promotes desensitization. |
| Function | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Protein Name | Leukotriene B4 Receptor 1Ltb4-R 1Ltb4-R1Chemoattractant Receptor-Like 1G-Protein Coupled Receptor 16P2y Purinoceptor 7P2y7 |
| Database Links | Reactome: R-HSA-391906Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leukotriene B4 Receptor 1 antibodyAnti-Ltb4-R 1 antibodyAnti-Ltb4-R1 antibodyAnti-Chemoattractant Receptor-Like 1 antibodyAnti-G-Protein Coupled Receptor 16 antibodyAnti-P2y Purinoceptor 7 antibodyAnti-P2y7 antibodyAnti-LTB4R antibodyAnti-BLT antibodyAnti-BLT1 antibodyAnti-BLTR antibodyAnti-CMKRL1 antibodyAnti-GPR16 antibodyAnti-P2RY7 antibody |
Information sourced from Uniprot.org