| Short Description : | Rabbit polyclonal LRIG1 (816-1093) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRIG1 |
| Gene ID: | 26018 |
| Uniprot ID: | LRIG1_HUMAN |
| Immunogen Region: | 816-1093 |
| Immunogen Sequence: | YQTRKKSEEYSVTNTDETVV PPDVPSYLSSQGTLSDRQET VVRTEGGPQANGHIESNGVC PRDASHFPEPDTHSVACRQP KLCAGSAYHKEPWKAMEKAE GTPGPHKMEHGGRVVCSDCN TEVDCYSRGQAFHPQPVSRD SAQPSAPNGPEPGGSDQEHS PHHQCSRTAAGSCPECQGSL YPSNHDRMLTAVKKKPMASL DGKGDSSWTLARLYHPDSTE LQPASSLTSGSPERAEAQY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 816-1093 of human LRIG1 (NP_056356.2). |
| Tissue Specificity | Widely expressed. |
| Function | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. |
| Protein Name | Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 1Lig-1 |
| Database Links | Reactome: R-HSA-177929Reactome: R-HSA-6807004Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 1 antibodyAnti-Lig-1 antibodyAnti-LRIG1 antibodyAnti-LIG1 antibody |
Information sourced from Uniprot.org
