| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LNPEP |
| Gene ID: |
4012 |
| Uniprot ID: |
LCAP_HUMAN |
| Immunogen Region: |
1-110 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_005566.2). |
| Immunogen Sequence: |
MEPFTNDRLQLPRNMIENSM FEEEPDVVDLAKEPCLHPLE PDEVEYEPRGSRLLVRGLGE HEMEEDEEDYESSAKLLGMS FMNRSSGLRNSATGYRQSPD GACSVPSART |
| Tissue Specificity | Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. |
| Post Translational Modifications | The pregnancy serum form is derived from the membrane-bound form by proteolytic processing. N-glycosylated. |
| Function | Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. |
| Protein Name | Leucyl-Cystinyl AminopeptidaseCystinyl AminopeptidaseInsulin-Regulated Membrane AminopeptidaseInsulin-Responsive AminopeptidaseIrapOxytocinaseOtasePlacental Leucine AminopeptidaseP-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form |
| Database Links | Reactome: R-HSA-1236977Reactome: R-HSA-1445148Reactome: R-HSA-983168 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIn Brain Only The Membrane-Bound Form Is FoundThe Protein Resides In Intracellular Vesicles Together With Glut4 And Can Then Translocate To The Cell Surface In Response To Insulin And/Or OxytocinLocalization May Be Determined By Dileucine Internalization MotifsAnd/Or By Interaction With TankyrasesLeucyl-Cystinyl AminopeptidasePregnancy Serum Form: SecretedDuring Pregnancy Serum Levels Are Low In The First TrimesterRise Progressively During The Second And Third Trimester And Decrease Rapidly After Parturition |
| Alternative Antibody Names | Anti-Leucyl-Cystinyl Aminopeptidase antibodyAnti-Cystinyl Aminopeptidase antibodyAnti-Insulin-Regulated Membrane Aminopeptidase antibodyAnti-Insulin-Responsive Aminopeptidase antibodyAnti-Irap antibodyAnti-Oxytocinase antibodyAnti-Otase antibodyAnti-Placental Leucine Aminopeptidase antibodyAnti-P-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form antibodyAnti-LNPEP antibodyAnti-OTASE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
