| Short Description : | Rabbit polyclonal anti-Protein LMBR1L (220-270 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LMBR1L |
| Gene ID: | 55716 |
| Uniprot ID: | LMBRL_HUMAN |
| Immunogen: | Synthesized peptide derived from the human LMBRL at the amino acid range 220-270 |
| Immunogen Region: | 220-270 aa |
| Specificity: | This antibody detects endogenous levels of LMBRL at Human/Mouse |
| Function | Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway. In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels. Acts as a LCN1 receptor and can mediate its endocytosis. |
| Protein Name | Protein Lmbr1lLimb Region 1 Protein Homolog-LikeLipocalin-1-Interacting Membrane ReceptorLimr |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Protein Lmbr1l antibodyAnti-Limb Region 1 Protein Homolog-Like antibodyAnti-Lipocalin-1-Interacting Membrane Receptor antibodyAnti-Limr antibodyAnti-LMBR1L antibodyAnti-KIAA1174 antibodyAnti-LIMR antibodyAnti-UNQ458 antibodyAnti-PRO783 antibody |
Information sourced from Uniprot.org
