Anti-Lipid phosphate phosphohydrolase 3 antibody (179-196 aa) [7H7D3] (STJA0040759)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeMix of IgG1, IgG2a & IgG2b
ImmunogenA synthetic peptide from human LPP3 (179-196 aa) conjugated to KLH.
General Information
| Short Description | Mouse monoclonal anti-Lipid phosphate phosphohydrolase 3 (179-196 aa) for use in FC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7H7D3 |
| Isotype | Mix of IgG1, IgG2a & IgG2b |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 2-3 ยตg/mLIHC 0.5-2 ยตg/mL |
| Formulation | Lyophilized from PBS pH 7.4 |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 100 uL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8ยฐC (lyophilized formulations). After reconstitution, aliquot and store at |
Target Information
| Gene Symbol | PLPP3 |
| Gene ID | 8613 |
| Uniprot ID | PLPP3_HUMAN |
| Immunogen | A synthetic peptide from human LPP3 (179-196 aa) conjugated to KLH. |
| Immunogen Region | 179-196 aa |
| Immunogen Sequence | Human |
| Specificity | Confirmed by over-expression of human LPP3 cDNA. Human. |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart and placenta. |
| Post Translational Modifications | N-glycosylated. Contains high-mannose oligosaccharides. |
| Function | Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines. By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function. Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers. Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis. |
| Protein Name | Phospholipid Phosphatase 3Lipid Phosphate Phosphohydrolase 3Pap2-BetaPhosphatidate Phosphohydrolase Type 2bPhosphatidic Acid Phosphatase 2bPap-2bPap2bVascular Endothelial Growth Factor And Type I Collagen-Inducible ProteinVcip |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneMembrane RaftCycles Between The Endoplasmic Reticulum And The Golgi |
| Alternative Antibody Names | Anti-Phospholipid Phosphatase 3 antibodyAnti-Lipid Phosphate Phosphohydrolase 3 antibodyAnti-Pap2-Beta antibodyAnti-Phosphatidate Phosphohydrolase Type 2b antibodyAnti-Phosphatidic Acid Phosphatase 2b antibodyAnti-Pap-2b antibodyAnti-Pap2b antibodyAnti-Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein antibodyAnti-Vcip antibodyAnti-PLPP3 antibodyAnti-LPP3 antibodyAnti-PPAP2B antibody |
Information sourced from Uniprot.org