| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart and placenta. |
| Post Translational Modifications | N-glycosylated. Contains high-mannose oligosaccharides. |
| Function | Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines. By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function. Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers. Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis. |
| Protein Name | Phospholipid Phosphatase 3Lipid Phosphate Phosphohydrolase 3Pap2-BetaPhosphatidate Phosphohydrolase Type 2bPhosphatidic Acid Phosphatase 2bPap-2bPap2bVascular Endothelial Growth Factor And Type I Collagen-Inducible ProteinVcip |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneMembrane RaftCycles Between The Endoplasmic Reticulum And The Golgi |
| Alternative Antibody Names | Anti-Phospholipid Phosphatase 3 antibodyAnti-Lipid Phosphate Phosphohydrolase 3 antibodyAnti-Pap2-Beta antibodyAnti-Phosphatidate Phosphohydrolase Type 2b antibodyAnti-Phosphatidic Acid Phosphatase 2b antibodyAnti-Pap-2b antibodyAnti-Pap2b antibodyAnti-Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein antibodyAnti-Vcip antibodyAnti-PLPP3 antibodyAnti-LPP3 antibodyAnti-PPAP2B antibody |
Information sourced from Uniprot.org
