| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LIMCH1 |
| Gene ID: | 22998 |
| Uniprot ID: | LIMC1_HUMAN |
| Immunogen Region: | 150-450 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human LIMCH1 (NP_001106189.1). |
| Immunogen Sequence: | LKEFEGLLAQMRKDTDDIES PKRSIRDSGYIDCWDSERSD SLSPPRHGRDDSFDSLDSFG SRSRQTPSPDVVLRGSSDGR GSDSESDLPHRKLPDVKKDD MSARRTSHGEPKSAVPFNQY LPNKSNQTAYVPAPLRKKKA EREEYRKSWSTATSPLGGER PFRYGPRTPVSDDAESTSMF DMRCEEEAAVQPHSRARQEQ LQLINNQLREEDDKWQDDLA RWKSRRRSVSQDLIKKEEE |
| Function | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. |
| Protein Name | Lim And Calponin Homology Domains-Containing Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonStress Fiber |
| Alternative Antibody Names | Anti-Lim And Calponin Homology Domains-Containing Protein 1 antibodyAnti-LIMCH1 antibodyAnti-KIAA1102 antibody |
Information sourced from Uniprot.org
