Anti-LIMCH1 antibody (150-450) (STJ119704)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LIMCH1 (150-450) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LIMCH1 |
| Gene ID | 22998 |
| Uniprot ID | LIMC1_HUMAN |
| Immunogen Region | 150-450 |
| Immunogen Sequence | LKEFEGLLAQMRKDTDDIES PKRSIRDSGYIDCWDSERSD SLSPPRHGRDDSFDSLDSFG SRSRQTPSPDVVLRGSSDGR GSDSESDLPHRKLPDVKKDD MSARRTSHGEPKSAVPFNQY LPNKSNQTAYVPAPLRKKKA EREEYRKSWSTATSPLGGER PFRYGPRTPVSDDAESTSMF DMRCEEEAAVQPHSRARQEQ LQLINNQLREEDDKWQDDLA RWKSRRRSVSQDLIKKEEE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human LIMCH1 (NP_001106189.1). |
Additional Info
| Function | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. |
| Protein Name | Lim And Calponin Homology Domains-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonStress Fiber |
| Alternative Antibody Names | Anti-Lim And Calponin Homology Domains-Containing Protein 1 antibodyAnti-LIMCH1 antibodyAnti-KIAA1102 antibody |
Information sourced from Uniprot.org