| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LILRB4 (22-259) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LILRB4 |
| Gene ID: |
11006 |
| Uniprot ID: |
LIRB4_HUMAN |
| Immunogen Region: |
22-259 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2). |
| Immunogen Sequence: |
QAGPLPKPTLWAEPGSVISW GNSVTIWCQGTLEAREYRLD KEESPAPWDRQNPLEPKNKA RFSIPSMTEDYAGRYRCYYR SPVGWSQPSDPLELVMTGAY SKPTLSALPSPLVTSGKSVT LLCQSRSPMDTFLLIKERAA HPLLHLRSEHGAQQHQAEFP MSPVTSVHGGTYRCFSSHGF SHYLLSHPSDPLELIVSGSL EGPRPSPTRSVSTAAGPEDQ PLMPTGSVPHSGLRRHWE |
| Tissue Specificity | Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung. |
| Function | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4B4Cd85 Antigen-Like Family Member KImmunoglobulin-Like Transcript 3Ilt-3Leukocyte Immunoglobulin-Like Receptor 5Lir-5Monocyte Inhibitory Receptor Hm18Cd Antigen Cd85k |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLigand Binding Leads To Internalization And Translocation To An Antigen-Processing Compartment |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 antibodyAnti-B4 antibodyAnti-Cd85 Antigen-Like Family Member K antibodyAnti-Immunoglobulin-Like Transcript 3 antibodyAnti-Ilt-3 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 5 antibodyAnti-Lir-5 antibodyAnti-Monocyte Inhibitory Receptor Hm18 antibodyAnti-Cd Antigen Cd85k antibodyAnti-LILRB4 antibodyAnti-ILT3 antibodyAnti-LIR5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
