Anti-LILRB2 antibody (22-598) (STJ112174)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LILRB2 (22-598) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LILRB2 |
| Gene ID | 10288 |
| Uniprot ID | LIRB2_HUMAN |
| Immunogen Region | 22-598 |
| Immunogen Sequence | QTGTIPKPTLWAEPDSVITQ GSPVTLSCQGSLEAQEYRLY REKKSASWITRIRPELVKNG QFHIPSITWEHTGRYGCQYY SRARWSELSDPLVLVMTGAY PKPTLSAQPSPVVTSGGRVT LQCESQVAFGGFILCKEGED EHPQCLNSQPHARGSSRAIF SVGPVSPNRRWSHRCYGYDL NSPYVWSSPSDLLELLVPGV SKKPSLSVQPGPVMAPGES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-240 of human LILRB2/CD85d/ILT4 (NP_005865.3). |
Additional Info
| Tissue Specificity | Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK) cells. Expressed in B cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2Lir-2Leukocyte Immunoglobulin-Like Receptor 2Cd85 Antigen-Like Family Member DImmunoglobulin-Like Transcript 4Ilt-4Monocyte/Macrophage Immunoglobulin-Like Receptor 10Mir-10Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 antibodyAnti-Lir-2 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 2 antibodyAnti-Cd85 Antigen-Like Family Member D antibodyAnti-Immunoglobulin-Like Transcript 4 antibodyAnti-Ilt-4 antibodyAnti-Monocyte/Macrophage Immunoglobulin-Like Receptor 10 antibodyAnti-Mir-10 antibodyAnti-Cd Antigen Cd85d antibodyAnti-LILRB2 antibodyAnti-ILT4 antibodyAnti-LIR2 antibodyAnti-MIR10 antibody |
Information sourced from Uniprot.org