| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LILRB2 |
| Gene ID: | 10288 |
| Uniprot ID: | LIRB2_HUMAN |
| Immunogen Region: | 22-598 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-240 of human LILRB2/CD85d/ILT4 (NP_005865.3). |
| Immunogen Sequence: | QTGTIPKPTLWAEPDSVITQ GSPVTLSCQGSLEAQEYRLY REKKSASWITRIRPELVKNG QFHIPSITWEHTGRYGCQYY SRARWSELSDPLVLVMTGAY PKPTLSAQPSPVVTSGGRVT LQCESQVAFGGFILCKEGED EHPQCLNSQPHARGSSRAIF SVGPVSPNRRWSHRCYGYDL NSPYVWSSPSDLLELLVPGV SKKPSLSVQPGPVMAPGES |
| Tissue Specificity | Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK) cells. Expressed in B cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 Lir-2 Leukocyte Immunoglobulin-Like Receptor 2 Cd85 Antigen-Like Family Member D Immunoglobulin-Like Transcript 4 Ilt-4 Monocyte/Macrophage Immunoglobulin-Like Receptor 10 Mir-10 Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 antibody Anti-Lir-2 antibody Anti-Leukocyte Immunoglobulin-Like Receptor 2 antibody Anti-Cd85 Antigen-Like Family Member D antibody Anti-Immunoglobulin-Like Transcript 4 antibody Anti-Ilt-4 antibody Anti-Monocyte/Macrophage Immunoglobulin-Like Receptor 10 antibody Anti-Mir-10 antibody Anti-Cd Antigen Cd85d antibody Anti-LILRB2 antibody Anti-ILT4 antibody Anti-LIR2 antibody Anti-MIR10 antibody |
Information sourced from Uniprot.org