Anti-LILRA2 antibody (121-170 aa) (STJ96831)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LILRA2 at the amino acid range 121-170
General Information
| Short Description | Rabbit polyclonal anti-Leukocyte immunoglobulin-like receptor subfamily A member 2 (121-170 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LILRA2 |
| Gene ID | 11027 |
| Uniprot ID | LIRA2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human LILRA2 at the amino acid range 121-170 |
| Immunogen Region | 121-170 aa |
| Specificity | LIR-7 Polyclonal Antibody detects endogenous levels of LIR-7 protein. |
Additional Info
| Function | Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2Cd85 Antigen-Like Family Member HImmunoglobulin-Like Transcript 1Ilt-1Leukocyte Immunoglobulin-Like Receptor 7Lir-7Cd Antigen Cd85h |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Secreted |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 antibodyAnti-Cd85 Antigen-Like Family Member H antibodyAnti-Immunoglobulin-Like Transcript 1 antibodyAnti-Ilt-1 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 7 antibodyAnti-Lir-7 antibodyAnti-Cd Antigen Cd85h antibodyAnti-LILRA2 antibodyAnti-ILT1 antibodyAnti-LIR7 antibody |
Information sourced from Uniprot.org